Feminizing Hormone Replacement Therapy for MtF Transition

Episode 9

Feminizing Hormone Therapy for MtF Transition

In Episode 9, Erin Everett, NP-C, gives an overview of Feminizing Hormone Therapy medications for a Male to Female MtF Transition. Erin discusses the prescribing guidelines for, and the expected effects of, feminizing hormones 17 beta-Estradiol, Estradiol Valerate, and Estradiol Cypionate. She also covers the risks, side effects, and benefits of Spironolactone and Progesterone.

About This Episode

In episode nine of Exclusively Inclusive, Erin Everett, NP-C, provides an in-depth overview of Feminizing Hormone Therapy for a MtF Transition.

During the episode, your host discusses the uses and differences between bioidentical feminizing hormones 17 beta-Estradiol, Estradiol Valerate, and Estradiol Cypionate. She covers the prescribing guidelines and expected effects of each of these feminizing hormones, as well as:

  • the administration (oral vs. intramuscular injection)
  • benefits of dosing twice daily (energy levels, libido, mood, etc.)
  • potential risks, benefits, and side effects of their use

Further on in the episode, Erin discusses the popular androgen blocker Spironolactone and its dosing, benefits, risks, and side effects including increased urination and fatigue.

Rounding out episode nine, Erin covers the use of Progesterone for MtF Transitions, as it is not a key player in feminizing, but has several anecdotal benefits to a MtF transition such as softening of the skin, reduction of terminal hair growth, weight distribution, and promotion of breast tissue and areola development.

Episode Links:

Feminizing Hormone Therapy for MtF Transition

Join The Conversation


  1. Very impressive..

    Finally some straight-forward, non judgmental advice.

    Thank you for this Feminizing Hormone pod cast.

  2. I loved your podcast on mtf hrt. I have decided to come to you for my hormones. You are awesome !!!!

  3. Interesting info. I just started this year, but I also have GERD. Gerd and high estrogen doses don’t go well together. Especially at night. And if I take a dosage at night, it really causes insanity with my sleep. I get acid reflux coming up into my throat and it’s awful. So the only way I can take a higher dosage is in the mornings when I first wake up. So I can only get the once a day. Also my doctor had told me to dissolve under tongue. So I’m glad you said that’s not needed.

  4. Thanks for all your info on this. It’s interesting because I just started back on HRT after being off for 15 years. I will allergic to Spiro and had Kidney problems. It’s funny because I’m on a high dosage of the b17 estrogen and my doctor told me to dissolve under the tongue. I liked what you said that I can just swallow. She also put my on Finasteride. Something that wasn’t available 15 years ago, when I found I was allergic to Spiro. I’m very excited about my transition.

  5. Thank you for such great straightforward information on providing healthcare to gender diverse individuals. I am a nurse practitioner who recently started to provide transgender care.

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